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KMID : 0379520010170020159
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한국독성학회지
2001 Volume.17 No. 2 p.159 ~ p.161
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Anti-emetic Effect of Ondaron in Ferrets
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Lee Byung-Mu
Choi Seul-Min
Cho Hyeon
Ahn Byoung-Ok
Kim Won-Bae
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Abstract
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The anti-emetic effect of a 5-HT_3 receptor antagonist, Ondaron, was compared with that of the approved ondansetron agent, ZofrancircledR in the ferrets. Emesis was induced by single intraperitoneal injection of cisplatin 10 mg/kg, and Ondaron or ZofrancircledR was injected intraperitoneally in a dose of 1.0 mg/kg, respectively. Ondaron and ZofrancircledR effectively antagonised the emetic response for 4 hours after injection. They significantly reduced the number of vomiting and retching, and prolonged the latency to the first episode. The anti-emetic effect of Ondaron was almost the equal to that of ZofrancircledR. These results suggest that Ondaron is an effective anti-emetic agent against cisplatin-induced emesis, and its anti-emetic potency is similar to that of 5-HT_3 receptor abtagonist, ZofrancircledR.
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KEYWORD
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Ondansetron, Ondaron, Anti-emetic, Ferret
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